Based on the Longxinling tunnel project, the sequenced excavation of quadruple neighbor tunnel is carefully simulated on the FLAC3D platform, and the distribution of ground pressure carried by the first lining is well focused. The numerical simulation results show that: The distribution of ground pressure is influenced by the excavation sequence significantly when the main and auxiliary tunnels are excavated. The vertical and horizontal pressures carried by the first lining take the form of＂single peak＂, due to the existence of vertical and horizontal supports in the unilateral pilot tunneling method. On the scenario of main tunnel excavation, the vertical and horizontal pressures carried by the first lining take the form of＂double peaks＂, due to the existence of two vertical supports and one horizontal support in the bilateral pilot tunneling method. Comparing to the regular separated tunnels, the excavation of two main tunnels leads to the increasing of ground pressure upon its neighbor tunnels. Especially, the increment of maximum ground pressure may reach 50% upon its neighbor side. These researches could provide some reference for the design and the construction of large section neighbor tunnels.