Based on the deep foundation pit engineering of Wangyue Road Station of Changsha Metro Line 6, Midas GTS was used to simulate the layered excavation and support of foundation pit. Ground wall displacement, internal support axial force and ground settlement were analyzed. The influence factors of the deformation characteristics of the retaining structure were analyzed by comparing the numerical simulation with the actual monitoring data. The results show that the deformation of the retaining structure on both sides of the foundation pit is obviously different under the action of eccentric pressure. The horizontal displacement of the pile body on the non-eccentric pressure side is larger than that on the eccentric pressure side. The ground settlement on both sides of the non-eccentric pressure side and the eccentric pressure side has an obvious space effect. The maximum ground settlement around the side-pit is larger than that of the non-side-pit. The deformation of the side-pit can be effectively controlled by adding large diameter bored piles and steel angle braces. The results of numerical simulation are basically consistent with the measured results, which provide a scientific basis for the rational design and safe construction of deep foundation pit of metro station.