To analyze the seismic fragility analysis of a high pier multi-span continuous rigid bridge in southwest of China，the finite element model was established，and the IDA method was used to analyze the susceptibility of five double-limb thin-walled piers of the bridge using the displacement ductility ratio as the seismic damage index. And the first-order limit method was used to analyze the susceptibility of the whole bridge. The research results show that the damage probability of bridge induced by transverse seismic waves than that by direction seismic. When multi-span continuous rigid bridge piers are symmetrically arranged，and the height is the same，the seismic vulnerability is similar. The higher the pier arranged in the symmetrical position，the lower the damage probability induced by the earthquake along the bridge，while the transverse seismic action is not obvious. It can provide reference for bridge damage assessment during earthquake.