In order to ensure that the force of each component of the long-span hybrid composite girder cable-stayed bridge can meet the requirements of the specification during the mid-span closing process and reach a ideal state after the bridge is completed,the Yanpingba Yangtze River Bridge is taken as the research object. Considering the structural force and construction characteristics of the bridge,the finite element analysis of the bridge closing process was performed. The influence of the temperature and the hoisting plan of the main longitudinal beam of the closing segment on the structural force and the bridge status during the mid-span closing process were studied. The research results show that the temperature mainly affects the width of the closure and the tower's deviation after completion of the bridge. The hoisting scheme of the main longitudinal beams of the closing segment mainly affects the stress of the bridge deck during the closing process and the displacement of the main girder after the completion of the bridge. This research ensures the successful and accurate of bridge closing ,saves construction costs,and also provides a reference for the closing construction of similar bridges.