In order to investigate the effect of acid rain on the anti-skid performance of permeable asphalt pavement, the corrosion of the OGFC-13 and the AC-13 asphalt mixtures was simulated by cyclic immersion. The cyclic action of tire load was simulated with the help of the small accelerated loading test, and the anti-skid performance of the specimens was detected and evaluated using the laser profiler and the pendulum friction coefficient meter. And the effects of acid concentration and soaking period on the skid resistance of the mixture were compared and analyzed, as well as the skid resistance durability of the two mixtures. The results show that acid corrosion will lead to peeling of asphalt film. And the slip resistance of the mixes under cyclic loading undergoes three phases: rapid decay, slow decay and stabilization. With the increase of acid concentration and soaking period, it accelerates the decay of asphalt mixtures' anti-skid performance, reducing the mixtures' anti-skid durability performance. Compared with the AC-13 asphalt mixture, the OGFC-13 asphalt mixture has good texture structure after the asphalt film is peeled off, which can provide stronger strength in acidic environment.