In order to improve the moisture resistance and low temperature performance of Thiopave modified asphalt mixture, dipentene (DIP) and sulfur were added and stirred evenly at high temperature, followed by adding ethylhexyl acrylate (EHA) and stirred well at high temperature around 140 ℃. The speed of mixer was slowly increased to 1 500 r/min, and after reacting for 4 h, the Thiopave particles were cooled to room temperature for pretreatment. In the meantime, the modification mechanism and mixture road performance with its mechanical properties were investigated comprehensively. The results showed that the sulfur molecular chain became longer after the addition of DIP and EHA, the surface energy and polar fraction of the binder were increased. Compared with the Thiopave modified asphalt mixture, the high temperature performance of enhanced sulfur modified asphalt mixture was slightly reduced, while the moisture resistance and low temperature crack resistance were significantly improved. As compared to the unmodified asphalt mixture pavement, the total vertical deformation and deformation contribution rate caused by the surface course of the reinforced sulfur modified asphalt mixture pavement decreased significantly. It was revealed that 1% DIP and 0.5% EHA are recommended as the optimum dosage to apparently improve the road performance and mechanical properties of the enhanced sulfur modified asphalt mixture.