An finite element model of wide cable-stayed bridge and refined finite element model of vehicle are established for the purpose of studying the dynamic responses under customized transportation vehicle (CTV), based on a practical engineering background. Compared with traditional methods, a more realistic simulation for vehicle-bridge coupled vibration is realized by using the contact algorithm within LS-DYNA. According to the parameters of vehicle type, lane and speed, the obtained conclusion from contrastive analysis of bridge's vibration response in different working conditions are as follows. When CTV passes wide cable-stayed bridge, it brings greater vertical deflection and cable force to bridge compared with standard vehicles. Amplitude of bridge's vertical displacement and cable force in side lane working condition is larger than that in middle lane working condition. The increase of CTV's passing speed brings greater vertical displacement and cable force, and the sensitivity of bridge dynamic responses to vehicle speed is higher in side lane working condition compared with the middle lane working condition.