In order to ensure that the stress of each component could meet the requirements of the specification during the wet joint pouring process of the bridge deck after the steel girder′s closure in the mid-span closed section of the long-span hybrid composite beam cable-stayed bridge, and it could reach the ideal bridge state after the reasonable finished state of the bridge, the Yanpingba Yangtze River Bridge was selected as the research object, and its finite element analysis of wet joint pouring of bridge deck in the closure process of the bridge was carried out by considering the structural forces and construction characteristics of the bridge. As for the last standard section and closure section of the bridge, the effects of four schemes with different construction sequences for the three processes (e.g. wet joint pouring and waiting for strength grade, bridge deck crane removal, and prestressed beam piercing) and the position of the bridge deck crane on the deck stress of the mid-span closed section and its adjacent sections were studied in this paper, respectively. The results show that the construction scheme in which the wet joints in the affected area of the bridge deck crane are poured together with wet joints in the closure section produce the smallest tensile stress on the deck. The risk of cracking of the bridge deck could be reduced by following the sequence of tensioning the prestressing first and then removing the crane, if the wet joints in the closure section have been poured separately. Among the four schemes, the tensile stress of the wet joint of the bridge deck which exceeds the limit could be reduced to the specification requirements when the station of the bridge deck crane is reasonable.