The slag sand-fiber asphalt mixture was prepared by using magnesite fiber and slag sand instead of limestone machine-made sand. The pavement performance of the mixture was evaluated, and the reasonable content of slag sand was explored high temperature rutting resistance, low temperature cracking resistance, and water damage resistance was measured. Based on the study of raw materials such as slag sand and brucite fiber, the characteristics of slag sand and brucite fiber and the feasibility of their joint application in asphalt mixture were evaluated. The optimum oil stone ratio of the mixture with different slag sand and brucite fiber content was determined. The road performance of slag sand-fiber asphalt mixture was evaluated by laboratory tests of high and low temperature and water stability. The grading of slag sand produced in different periods is very different, and it needs to be adjusted after grading and screening to meet the grading requirements. The slag sand does not contain toxic substances and will not cause harm to the environment and human physical and mental health. Brucite fiber can improve the acidic environment of slag sand asphalt mixture and enhance the adhesion ability between asphalt and ore. With the addition of slag sand, the high and low temperature stability and water stability of asphalt mixture are reduced to different degrees, and the greater the amount of addition, the more significant the decrease.With the addition of brucite fiber, the related road performance of slag sand asphalt mixture is improved. The water stability of asphalt mixture containing 20% slag sand and 0.4% brucite fiber is equivalent to that of conventional AC-13C asphalt mixture, and the high and low temperature performance is better than that of conventional AC-13C asphalt mixture. It is feasible to use slag sand as fine aggregate instead of limestone sand to prepare hydrogypsum fiber asphalt mixture, which has considerable economic and environmental benefits.