Due to the complex and unique stress structure of long-span four-arch tunnels, the mid-partition wall and the lining of the first tunnel are prone to damage or even destruction under blasting loads. Based on the engineering context of the Guanyinyan four-arch tunnel in Yinxing Road, Changsha, the blasting vibration velocity of the advanced tunnel lining has been measured. Through regression analysis, the propagation law of vibration waves in the advanced tunnel has been established. Additionally, numerical simulation methods have been employed to analyze the vibration velocity and displacement response of the mid-partition wall and tunnel lining under blasting loads. The results indicate that the vibration velocity of the mid-partition wall is significant within 30 meters along the longitudinal direction of the blasting excavation face. The maximum displacement occurs at the shoulder on the blasting side of the mid-partition wall, followed by the top, while the least displacement is observed at the foot behind the blasting side. During blasting in the right auxiliary tunnel, the vibration velocity on the blasting side of the right main tunnel, particularly near the right auxiliary tunnel, is higher, with the highest vibration velocity recorded at the haunch of the blasting side. Notably, the peak vibration velocity of the haunch in the right main tunnel lining on the blasting side is approximately 16 times greater than that in the left main tunnel and 40 times greater than that in the left auxiliary tunnel lining.