Typhoon is a key load influencing the safety of large-span and tall structures in the coastal areas of China. There is a great difference between typhoon wind profile and normal wind profile. Accurate estimation of design wind profile of a typhoon is very important to guide the wind resistance design of coastal structures. In this paper, the wind profiles of 8 major standards and specifications on open landforms at home and abroad are selected to compare with the measured typhoon profiles. The current specifications are difficult to reflect the variation characteristics of typhoon profiles with height and do not include the evolution of typhoon profiles with spatial location. In response to this, the paper proposes three methods for design wind profile of typhoons:1. design of wind profile based on the specification；2. design of combined wind profile based on the same recurrence period at different heights；3. design of the real wind profile based on the wind speed in the recurrence period at specific heights. Method 2 and 3 consider the characteristics of the typhoon wind profile changing with height. The calculated results show that the wind profiles obtained by method 2 and 3 are greater than the standard profile, and the profile obtained by method 2 is close to the mean profile obtained by method 3, but the profile obtained by method 2 may not exist in real typhoons. Nearly half of the real wind profile obtained by method 3 is higher than the result of method 2. The wind profile recommended in the current specification may be the result of underestimating the strength of actual wind profile of typhoons, and the wind profile based on the 100-year recurrence period at different heights cannot comprehensively reflect the real profile characteristics of typhoons. If only the static response of wind to buildings is considered, it is recommended to adopt the design wind profile of typhoons based on method 3 to ensure safety and reliability of structures.