[Purposes]To solve the problems of low efficiency and difficulty in achieving multi-performance synergy in the design of multi-component modified asphalt using the traditional trial-and-error method. [Methods] This paper introduces the response surface method to systematically optimize the dosages of nano-ZnO, OMMT, and SBS, and evaluates the conventional properties, high-temperature rheological properties, and anti-aging properties of the modified asphalt. [Findings]Under the optimal ratio (4%